Mapping physiological inputs from multiple photoreceptor systems to dopaminergic amacrine cells in the mouse retina
نویسندگان
چکیده
منابع مشابه
Inhibitory inputs tune the light response properties of dopaminergic amacrine cells in mouse retina.
Dopamine (DA) is a neuromodulator that in the retina adjusts the circuitry for visual processing in dim and bright light conditions. It is synthesized and released from retinal interneurons called dopaminergic amacrine cells (DACs), whose basic physiology is not yet been fully characterized. To investigate their cellular and input properties as well as light responses, DACs were targeted for wh...
متن کاملMultiple genes on chromosome 7 regulate dopaminergic amacrine cell number in the mouse retina.
PURPOSE The size of neuronal populations is modulated by gene variants that influence cell production and survival, in turn influencing neuronal connectivity, function, and disease risk. The size of the dopaminergic amacrine (DA) cell population is a highly heritable trait exhibiting sixfold variation among inbred strains of mice and is used here to identify genes that modulate the number of DA...
متن کاملDopaminergic innervation of A II amacrine cells in mammalian retina.
Dopaminergic amacrine cells were stained in cat, rat, and rabbit retina using an antibody against tyrosine hydroxylase (TH). Following intraocular injection of DAPI (4,6,diamidino-2-phenylindole), subsequent retinal whole-mount preparations revealed that the dopaminergic fiber plexus formed rings around amacrine cell bodies. Intracellular injection of Lucifer yellow (LY) into A II amacrine cell...
متن کاملDopaminergic amacrine cells in rabbit retina: a confocal microscopic study
Objective: To demonstrate the relationship between dopamicergic amacrine (DA) cells and AII amacrine cells and to characterize DA cells of the rabbit retina. Methods: Retinal whole mounts were doubleor triple-labeled using antibodies against tyrosine hydroxylase (TH), calretinin (CR), and vesicular glutamate transporter 1 (VGLUT1) which selectively label DA cells, AII amacrine cells, and all bi...
متن کاملPopulations of wide-field amacrine cells in the mouse retina.
We surveyed wide-field amacrine cells in the mouse, using a large series of retinas from a transgenic strain that expresses the green fluorescent protein (GFP) in isolated retinal cells. Wide-field cells were present in surprising diversity and number. They formed groups that could be defined by arbor depth, arbor size, and soma size. By conventional criteria, these populations of cells make up...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-08172-x